| Pair Name | Baicalein, Epirubicin | ||
| Phytochemical Name | Baicalein (PubChem CID: 5281605 ) | ||
| Anticancer drug Name | Epirubicin (PubChem CID: 41867 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Drug Name | Epirubicin |
| Adverse Reactions | Nausea, vomiting, diarrhoea, loss of appetite, inhibition of bone marrow haematopoiesis. This was inferred cold nature anticancer drug. |
| Recommendations | Hot: Pinellia ternata |
| Reference | ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899. ref_link |
| Pair Name | Baicalein, Epirubicin | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Apoptosis and autophagy | |||
| Gene Regulation | Up-regulation | Expression | ATG7 | hsa10533 |
| Up-regulation | Expression | BAX | hsa581 | |
| Up-regulation | Expression | BECN1 | hsa8678 | |
| Down-regulation | Expression | TGFB1 | hsa7040 | |
| In Vitro Model | Hep-G2 | Hepatoblastoma | Homo sapiens (Human) | CVCL_0027 |
| WI-38 | Healthy | Homo sapiens (Human) | CVCL_0579 | |
| Result | BTME (200μg/mL) significantly enhanced epirubicin's cytotoxicity against Hep-G2 cells and ameliorated its safety profile. BTME could exert anti-hepatocarcinoma effect by enhancing apoptosis and autophagy | |||
| No. | Title | Href |
|---|---|---|
| 1 | Chemotherapeutic effect of baicalein/epirubicin combination against liver cell carcinoma in-vitro: Inducing apoptosis and autophagy. Toxicol In Vitro. 2024 Mar;95:105744. doi: 10.1016/j.tiv.2023.105744. | Click |
